What is NIFTY?

Non-Invasive Fetal Trisomy (NIFTY) is a simple blood test that detects Down Syndrome and other genetic disorders without any risks to the fetus or mother.

NIFTY Advantages:

NIFTY is highly accurate, non-invasive, risk free and can be performed early in the pregnancy:

  • Highly Accurate: with next-generation sequencing technology NIFTY’s detection rate > 99.9%.
  • Non-invasive: Only 10ml of the mother’s blood from a vein is required.
  • Risk Free: Avoids intrauterine infection and induced miscarriage. Only a blood sample from the mother’s vein is required.
  • Early Detection: Performed as early as 10 weeks of gestation. This allows early detection for a better clinical decision.
  • Fast Results: 2-3 weeks turnaround time

Other Test Comparisons

nifty test compare to old method

Down Syndrome and More

Human somatic cells are diploid cells that contain 23 pairs of chromosomes. When chromosomes are lost in human cells it is called aneuploidy. This is a common cause of genetic defects in a fetus. Down Syndrome, Edwards’ Syndrome and Pautau Syndrome are the three most common autosomal chromosome aneuploidies. An extra copy of chromosome 21, 18 or 13 causes them respectively.

What is Down Syndrome (Trisomy 21)?

Down Syndrome (Trisomy 21) is the most commonly occurring chromosome abnormality. It is caused by the presence of an extra chromosome 21. Down Syndrome occurs in approximately 1 in 800 births. Affected individuals usually have unique facial and physical characteristics and most have mild to moderate intellectual disabilities accompanied by multiple organ abnormalities.

What is Edwards’ syndrome (Trisomy 18)?

Edwards’ Syndrome (Trisomy 18) is the second most common trisomy. IT is caused by the presence of an extra copy of chromosome 18 and occurs approximately 1 in every 5000 births. Trisomy 18 causes developmental disabilities and often life-threatening complications shortly after birth. These may include heart, intestine, esophageal, hand or foot deformities. It may also cause kidney defects, delayed growth or intellectual disabilities.

What is Patau Syndrome (Trisomy 13)?

Patau Syndrome (Trisomy 13) is caused by the presence of an extra copy of chromosome 13. It is the third most common trisomy and occurs 1 in every 10,000 births. Trisomy 13 is associated with severe intellectual and physical disabilities. It is often fatal in infants, causing death within the first weeks after birth.

NIFTY test is suitable for women who:

  • want prenatal screening of various genetic syndromes such as Patau Syndrome (Trisomy 13), Edwards’ Syndrome (Trisomy 18) and Down Syndrome (Trisomy 21).
  • are age 35 or older.
    morbidity of down syndrome
  • do not wish to receive invasive prenatal tests.
  • have had tests or examinations in the 1st and 2nd trimester that suggest high risk of genetic syndromes such as Down Syndrome.
  • are not suitable for invasive prenatal testing due to conditions such as placenta previa, risks of miscarriage, HBV or HIV infection.
  • have received IVF treatment.